A group of new drugs is on the scene for forensic toxicologists to isolate, identify and quantify, the Spice drugs (JWH-018,073 etc). As recent studies have shown these drugs metabolize very quickly into their hydroxylated forms. Until very recently the choice of derivative for these compounds has been unclear. With resources from UCT, scientists have used MSTFA to derivatize the hydroxylated form of JWH-018. This compound can easily be used by simple heating and cooling prior to injection. The MSTFA derivative forms a compound which does not interfere with the parent, and can be resolved using a standard GC-MS instrument in EI mode. Chromatogram and mass spectra are shown here for illustrative purposes.
Here is our current method for extracting these compounds: Synthetic Cannabinoids LC-MS/MS and GC-MS using Clean Screen® THC Urine
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