Forensic toxicologists that test post mortem samples are often challenged with extracting, identifying, and most importantly quantifying many drugs and their metabolites. This information is vital for medical examiners to offer interpretation into the cause and manner of a particular case. When toxicologists come across a new drug, the challenge becomes the development of a validated method. The Clean Screen DAU column, allows workers in the field of forensic toxicology to do exactly that. This powerful column, with its ability to extract a wide and diverse range of weak acid, neutral and basic drugs was utilized by Scott Larson and the toxicologists of Washington DC Chief Medical Examiner for the analysis of tapentadol and its metabolite N-desmethyltapentadol. The drug which is one of the newer pain medication drugs was extracted and quantified from post mortem samples of blood and tissue samples.
This work was reported in the July 2012 issue of Journal of Analytical Toxicology. The information gained from this analysis allows Forensic Toxicologists working in this field to be confident in the capability of the Clean Screen DAU to extract newer pain management drugs such as tapentadol.
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