In the Journal of Biomaterials and Tissue Engineering, Hedvika Davis, et al, used UCT Specialties silane T2910 (diethylenetriamine trimethoxysilylpropyldiethylenetriamine) in their in vitro CNS myelination model (J. Biomater. Tissue Eng. 2, 206-215, 2012).  The T2910, or DETA, modifies the surface of a glass coverslip.  Motorneurons are then attached to the coverslip via the T2910.  The motorneurons, in turn, were seeded with OPCs (oligiodendrocyte precursor cells) and then allowed to culture.  The DETA used gave the surface the following advantages:

·The tramine moiety of T2910 resembles the structure of spermidine, a well known growth factor

·T2910 is an aminosilane that forms a covalently bound, uniform, self-assembled monolayer on glass surfaces

·At physiologic pH, the amines in T2910 carry partial positive charges, providing a hydrophilic surface that promotes cellular attachment

·T2910 also promotes long-term cell survival because it is non-digestible by matrix proteases secreted by cells.

·By using T2910 micropatterning of the culture can now be performed using photolithorgraphy.  This cannot be performed using current attachment techniques.

UCT Specialties (Petrarch) continues to manufacture high quality specialty silanes, silicones, catalysts and coatings for a vast variety of manufacturing markets.  Coupled with our excellence in the Solid Phase Extraction chromatography markets, this demonstrates UCT Inc. as a leader for your silicon related chemistry products.

N-Octadecyltrichlorosilane (O9750) is used to create single and two-component gradient monolayers on silicon surfaces

Research conducted by Brandon D. Booth and associates at Vanderbilt University (B.D. Booth, et al., Tribological characterization of gradient monolayer films from trichlorosilanes in silicon, Colloids Surf. A: Physicochem. Eng. Aspects (2012)) recently published that n-octadecyltrichlorosilane from UCT Specialties (United Chemical Technologies) was used to create single and two-component gradient monolayers on silicon surfaces. Both of these techniques impart stronger tribological qualities to the surface.  In fact, the two-component gradient monolayer provides a more robust tribological interface demonstrated by increased stability in gradient frictional performance for at least 5 hours of continuous sliding.

UCT Specialties (Petrarch) continues to manufacture high quality specialty silanes, silicones, catalysts and coatings for a vast variety of manufacturing markets.  Coupled with our excellence in the Solid Phase Extraction chromatography markets, this demonstrates UCT Inc. as a leader for your silicon related chemistry products.

N-1-[3-(trimethoxysilyl)propyl]-diethylenetriamine (T2910)

Dr. Xiufung Gao and associates at the University of Central Florida (Journal Biomaterials (2012, 33 5723-5731)) have published a paper where N-1-[3-(trimethoxysilyl)propyl] diethylenetriamine (UCT Specialties Part #: T2910) was used in a biological medium to co-culture embryonic motoneurons and proprioceptive sensory neurons from dorsal root ganglia (DRG) in a defined serum-free medium on a synthetic silane substrate. Dr. Gao was researching in-vitro model systems for the study of spinal motor control and related pathologies such as spinal cord injury, muscular dystrophy and spasticity. Previous to this report, the in-vitro synaptic connection between proprioceptive sensory neurons and spinal motoneurons had not been demonstrated.

UCT Specialties manufactures high quality specialty Petrarch silanes, Petrarch silicones, catalysts and coatings for a vast variety of manufacturing markets.