Clinical toxicologists often face the challenge of working to quantify difficult and low concentration medications in human beings. Falling into this category is the series of compounds known as Bisphosphonates. These pharmaceuticals are prescribed to counter the effects of bone disorders. Bisphosphonates are known to be difficult to analyze due to their phoshonic acid functional groupings and high polar character. One of the main issues with working with these types of materials is to produce a clean extract for analysis by modern instrumentation such as LC-MS/MS.
In Australia, a team lead by Dr. Sussan Ghassabian, PharmD has recently reported a validated method for the analysis of Bisphosphonates in human plasma (Journal of Chromatography B ( November 2011)). This procedure employs UCT's CHQAX solid phase extraction sorbent. The QAX column (hydroxy counter ion) is part of a range of Clean Up Anion Exchange Sorbents manufactured to the highest technical quality which also includes CUNAX (a weak anion exchanger) and CUPAX (a very weak anion exchange sorbent). In the case of Dr. Ghassabian's analysis, the phosphonic acid were efficiently held by the CHQAX, while interfering compounds could be rinsed away, offering a much cleaner environment for elution, and further analysis of the medications via on column derivatization.
In Australia, a team lead by Dr. Sussan Ghassabian, PharmD has recently reported a validated method for the analysis of Bisphosphonates in human plasma (Journal of Chromatography B ( November 2011)). This procedure employs UCT's CHQAX solid phase extraction sorbent. The QAX column (hydroxy counter ion) is part of a range of Clean Up Anion Exchange Sorbents manufactured to the highest technical quality which also includes CUNAX (a weak anion exchanger) and CUPAX (a very weak anion exchange sorbent). In the case of Dr. Ghassabian's analysis, the phosphonic acid were efficiently held by the CHQAX, while interfering compounds could be rinsed away, offering a much cleaner environment for elution, and further analysis of the medications via on column derivatization.
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