Hair analysis for the presence of illicit drugs is becoming one of the most challenging types of forensic toxicological analysis. At this years SOFT meeting, Dr. Jeff Hackett will be presenting the results of a collaborative project involving Amphetamines and Synthetic Cathinones in hair samples (Poster P03). In this work, UCT's flagship sorbent Clean Screen DAU (CSDAU206) was employed to produce a highly efficient validated methodology for the simultaneous extraction of 4 Amphetamines (Amphetamine, methamphetamine, MDA, and MDMA) and 9 Synthetic Cathinones (Butylone, ethylone, flephedrone, mephedrone, methylone, methedrone, methcathinone (4-MEC), methylenedioxypyravalerone (MDPV) and pyravalerone) from 10 mg samples of hair. This new methodology which involves a short base digestion time followed by SPE and LC-MS/MS permits limits of quantitation (LOQ) of 0.05 ng/ mg, and detection(LOD) of 0.1 ng/ mg of sample to be achieved with excellent recoveries (greater than 95%) and minimal matrix effects (less than 6%). This newer methodology demonstrates the strength of the DAU sorbent in the analysis of not only familiar drugs but new and novel ones as well.
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