N-1-[3-(trimethoxysilyl)propyl]-diethylenetriamine (T2910)

Dr. Xiufung Gao and associates at the University of Central Florida (Journal Biomaterials (2012, 33 5723-5731)) have published a paper where N-1-[3-(trimethoxysilyl)propyl] diethylenetriamine (UCT Specialties Part #: T2910) was used in a biological medium to co-culture embryonic motoneurons and proprioceptive sensory neurons from dorsal root ganglia (DRG) in a defined serum-free medium on a synthetic silane substrate. Dr. Gao was researching in-vitro model systems for the study of spinal motor control and related pathologies such as spinal cord injury, muscular dystrophy and spasticity. Previous to this report, the in-vitro synaptic connection between proprioceptive sensory neurons and spinal motoneurons had not been demonstrated.

UCT Specialties manufactures high quality specialty Petrarch silanes, Petrarch silicones, catalysts and coatings for a vast variety of manufacturing markets.

Clean Screen DAU and Analysis of New Pain Medication Drug

Forensic toxicologists that test post mortem samples are often challenged with extracting, identifying, and most importantly quantifying many drugs and their metabolites. This information is vital for medical examiners to offer interpretation into the cause and manner of a particular case. When toxicologists come across a new drug, the challenge becomes the development of a validated method. The Clean Screen DAU column, allows workers in the field of forensic toxicology to do exactly that. This powerful column, with its ability to extract a wide and diverse range of weak acid, neutral and basic drugs was utilized by Scott Larson and the toxicologists of Washington DC Chief Medical Examiner for the analysis of tapentadol and its metabolite N-desmethyltapentadol. The drug which is one of the newer pain medication drugs was extracted and quantified from post mortem samples of blood and tissue samples.

This work was reported in the July 2012 issue of Journal of Analytical Toxicology. The information gained from this analysis allows Forensic Toxicologists working in this field to be confident in the capability of the Clean Screen DAU to extract newer pain management drugs such as tapentadol.

Clean Screen DAU Success in Mummified Body Drug Testing

One of the most difficult sample analysis for Forensic Toxicologists consist of decomposed tissue samples. This is because fatty materials produced by the decomposition process cause issues for instruments due to their solubility in organic solvents. This issue can easily be over overcome by the use of high quality Solid Phase Extraction (SPE) sorbents.

This is the case recently reported in the Journal of Forensic Sciences by Dr. Mario Giusiani and his team ( Department of Neurosciences, University of Pisa, Italy) who analyzed samples from body that had be missing for over 10 years. Samples of tissue were extracted using UCT's flagship sorbent Clean Screen DAU (ZSDAU020).  The team not only identified but also quantified the concentrations of Phenobarbital using GC-MS (without derivatization) in post mortem samples of liver, heart, lung, muscle and skin. This case demonstrates why Clean Screen DAU is the most popular SPE extraction column due to its unmatched analytical performance.

UCT to give QuEChERS talk and more at Midwest AOAC Meeting

UCT Food and Environmental Technical Specialist Don Shelly will be making three presentations at the 31st annual Midwest Section AOAC International Meeting and Exposition in St. Louis, Missouri, June 4 –7.  Don will be speaking on “An Improved Method for the Determination of Haloacetic acids and Dalapon in Water”, “C18 Sorbents and QuEChERS Clean-up:  Are Variations in Pesticide Recoveries Manufacturer Dependent?” and “Modified QuEChERS Procedure for the Analysis of Bisphenol A in Canned Food Products”. 

Visit www.midwestaoac.org/2012.html for more information.

UCT Presents work at TIAFT 2012 (June 3- 8th 2012)

As an active supporter of forensic endeavors around the world, UCT is proud to announce the presentation of research at this years annual meeting of The International Association of Forensic Toxicologists  (TIAFT). This years meeting is being held in the city of Hamamatsu (Japan) and brings together the worlds best toxicologists to discuss new developments in the area of forensic toxicology. UCT is known around the globe for its SPE sorbents and methodologies for assisting analysts extract, confirm and quantify drugs in various types of matrices.

The work being presented at TIAFT2012 involves the analysis of amphetamine type drugs (Amphetamine, Methamphetamine, MDA, amd MDMA) in small samples of hair (10 mg). The extraction was performed (after base digestion of samples) using UCT's flagship sorbent Clean Screen DAU (CSDAU206). Not only was the sorbent able to isolate the drugs, but the highly purified extract when tested by LC-MS/MS showed minimal matrix effects (<6%) and high recoveries (>95%) showing why this sorbent is highly recognised around the world as the market leader in forensic and clinical toxicological analyses for not only the amphetamine drugs but a wide and diverse range of drugs, poisons, and other medications often faced by analysts in these facilities.  

UCT Presentation at AECLDPA, La Rocholle, France, May 24-25 2012

The education of scientists around the world remains an important mission for UCT.  We are proud to announce that our own Dr. Jeff Hackett will be presenting work at the Annual Congress of Association of the Expert Chemists and Laboratories Departmental and Public Analysis (AECLDPA) in La Rochelle, France, May 24th-25th. This meeting brings together the top scientists in the analytical field of veterinary drug analysis.  Dr. Hackett will be discussing the extraction/analysis of beta-agonists and pharmaceutical residues in muscle tissue using UCT's premier solid phase extraction columns and equipment. These include the Clean Screen and XtrackT families of SPE cartridges. UCT is a reknowned manufacturer of SPE sorbents for forensic/clinical toxicology laboratories.  UCT is also known for its support in other areas such as Equine and Veterinary Toxicology. UCT's SPE sorbents are highly regarded for their reproducible results, which means higher productivity, efficiency and less analytical laboratory down time.

UCT Specialties exhibits at the American Coatings Show

UCT Specialties LLC, a leader in the specialized silane industry, will be exhibiting at the American Coatings Show in Indianapolis, Indiana,  May 8th–10th, 2012.  Come visit us at Booth #432 to receive our new 2012 UCT Specialties Catalog as well as brochures for Silane Coupling Agents and our Glass-clad PS200 coating.  We look forward to meeting with you at the show.