N-1-[3-(trimethoxysilyl)propyl]-diethylenetriamine (T2910)

Dr. Xiufung Gao and associates at the University of Central Florida (Journal Biomaterials (2012, 33 5723-5731)) have published a paper where N-1-[3-(trimethoxysilyl)propyl] diethylenetriamine (UCT Specialties Part #: T2910) was used in a biological medium to co-culture embryonic motoneurons and proprioceptive sensory neurons from dorsal root ganglia (DRG) in a defined serum-free medium on a synthetic silane substrate. Dr. Gao was researching in-vitro model systems for the study of spinal motor control and related pathologies such as spinal cord injury, muscular dystrophy and spasticity. Previous to this report, the in-vitro synaptic connection between proprioceptive sensory neurons and spinal motoneurons had not been demonstrated.

UCT Specialties manufactures high quality specialty Petrarch silanes, Petrarch silicones, catalysts and coatings for a vast variety of manufacturing markets.

Clean Screen DAU and Analysis of New Pain Medication Drug

Forensic toxicologists that test post mortem samples are often challenged with extracting, identifying, and most importantly quantifying many drugs and their metabolites. This information is vital for medical examiners to offer interpretation into the cause and manner of a particular case. When toxicologists come across a new drug, the challenge becomes the development of a validated method. The Clean Screen DAU column, allows workers in the field of forensic toxicology to do exactly that. This powerful column, with its ability to extract a wide and diverse range of weak acid, neutral and basic drugs was utilized by Scott Larson and the toxicologists of Washington DC Chief Medical Examiner for the analysis of tapentadol and its metabolite N-desmethyltapentadol. The drug which is one of the newer pain medication drugs was extracted and quantified from post mortem samples of blood and tissue samples.

This work was reported in the July 2012 issue of Journal of Analytical Toxicology. The information gained from this analysis allows Forensic Toxicologists working in this field to be confident in the capability of the Clean Screen DAU to extract newer pain management drugs such as tapentadol.

Clean Screen DAU Success in Mummified Body Drug Testing

One of the most difficult sample analysis for Forensic Toxicologists consist of decomposed tissue samples. This is because fatty materials produced by the decomposition process cause issues for instruments due to their solubility in organic solvents. This issue can easily be over overcome by the use of high quality Solid Phase Extraction (SPE) sorbents.

This is the case recently reported in the Journal of Forensic Sciences by Dr. Mario Giusiani and his team ( Department of Neurosciences, University of Pisa, Italy) who analyzed samples from body that had be missing for over 10 years. Samples of tissue were extracted using UCT's flagship sorbent Clean Screen DAU (ZSDAU020).  The team not only identified but also quantified the concentrations of Phenobarbital using GC-MS (without derivatization) in post mortem samples of liver, heart, lung, muscle and skin. This case demonstrates why Clean Screen DAU is the most popular SPE extraction column due to its unmatched analytical performance.